Luke has been an actor and performer on the Bombay stage since 1991. He was part of a dance and skit troupe led by Bharat Dabholkar from 1990 to 1994. He made his dramatic debut with William Shakespeare's Romeo and Juliet directed by Vickram Kapadia in 1996. Two years later Luke made his film debut with Kaizad Gustad's Bombay Boys. He played a pivotal role in Abhishek Kapoor's ROCK ON! Luke Kenny was also seen in the movie Banjo (2016) and Qarib Qarib Singlle (2017).
His 2020 release includes Tanhaji: The Unsung Warrior. Directed by Om Raut, the movie stars Ajay Devgn, Kajol and Saif Ali Khan in prominent roles.